In the News

LSU VET MED SCHOLAR AWARDED RESEARCH PUBLICATION GRANT IN ENGINEERING, MEDICINE AND SCIENCE

Education

PhD, Cornell University, 2014

MS, Pennsylvania State University, 2010

BS and BE, Tsinghua University (China), 2008

 

Research Interest

Huang lab studies the development and functions ­­of regulatory immunity and immune memory, during vaccination, infections and cancers.

 

Teaching Interest

Immunology

Virology

 

Selected Awards & Honors

2024, AAI ASPIRE Award

2024, COBRE Rising Star Award, National IDeA Symposium of Biomedical Research Excellence

2023, LSU Vet Med Distinguished Dissertation Award (Michael McGee)

2023, LSU Vet Med Distinguished Scholar Award

2022, LSU Alumni Association Rising Faculty Research Award

2022, Research Publication Grant in Engineering, Medicine and Science, American Association of University Women

2021, AAI Careers in Immunology Fellowship (PI: Weishan Huang; Fellow: Michael McGee)

2021, Zoetis Award for Veterinary Research Excellence

2019, AAI Public Policy Fellowship

2018, Faculty Scholarship, Summer Institute on the Future of Graduate Studie

 

Selected Publications

Anannya O, Huang W, August A. The kinase ITK controls a Ca2+-mediated switch that balances TH17 and Treg cell differentiation. Sci Signal. (2024)17(846):eadh2381.

Magazine N, Zhang T, Bungwon AD, McGee MC, Wu Y, Veggiani G, Huang W†. Immune Epitopes of SARS-CoV-2 Spike Protein and Considerations for Universal Vaccine Development. Immunohorizons. (2024) 8(3):214-226.

Zhang T, Magazine N, McGee MC, Carossino M, Veggiani G, Kousoulas KG, August A, Huang W†. Th2 and Th17-associated immunopathology following SARS-CoV-2 breakthrough infection in Spike-vaccinated ACE2-humanized mice. J Med Virol. (2024) 96(1):e29408.

McGee MC, Zhang T, Magazine N, Islam R, Carossino M and Huang W†. PD-1 and ICOS counterregulate tissue resident regulatory T cell development and IL-10 production during flu. Front Immunol. (2022) 13:984476.

McGee MC and Huang W†. Evolutionary conservation and positive selection of Influenza A Nucleoprotein CTL epitopes for universal vaccination. J Med Virol. (2022), 94(6):2578-2587. Editor’s Choice

Magazine N, Zhang T, Wu Y, McGee MC, Veggiani G, and Huang W†. Mutations and Evolution of the SARS-CoV-2 Spike Protein. Viruses. (2022) 14(3), 640.

Huang L, Ye K, Nidetz NF, Elmore JP, Limper CB, McGee MC, Southard TL, Russell DG, August A†, and Huang W†. Interleukin-2-inducible T-cell kinase deficiency impairs early pulmonary protection against Mycobacterium tuberculosis infection. Front Immunol. (2020) 10:3103.

Nidetz NF, McGee MC, Tse LV, Li C, Cong L, Li, Y, and Huang W†. Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery. Pharmacol Ther. (2020) 207: 107453.

Solouki S, August A†, and Huang W†. Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications. Pharmacol Ther. (2019) 201:39-50.

Huang W†, Solouki S, Carter C, Zheng SG, and August A†. Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages. Front Immunol. (2018) 9:2625.

Huang W†, Solouki S, Koylass N, Zheng SG, and August A†. ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells. Nat Commun. (2017) 8, 15871.

Complete List of Published Work in MyBibliography

 

Active Grant Funding

Modulation of ITK signaling for sustainable adoptive T cell therapy, NIH/NCI R21, Principal Investigator, 04/2024-03/2026

Programming designer DNA nanostructures for blocking enveloped viral infection, NIH/NIAID R21, Principal Investigator, 07/2023-06/2025

Integration of TCR signaling modular domains for sustainable CAR-T cell therapy, NIH/NIGMS: LSU Center for Pre-Clinical Cancer Research – Pilot, Principal Investigator, 07/2023-02/2025

Biomaterials for Targeted Modulation of Conventional Type 1 Dendritic Cells, NIH/NCI R01, Co-Investigator, 09/2022-08/2027

Markers and regulation of regulatory CD8+ T cells during influenza-induced lung immunopathology, NIH/NIAID R01, Principal Investigator, 07/2021-06/2026

 

Completed Grant Funding

Streamline Development of Synthetic High-affinity Binders for Rapid Diagnosis and Therapeutics of Emerging Infections, LSU Provost’s Fund – Big Idea Research Planning, Principal Investigator, 01/2023-12/2023, $75,000

Detection and Automatic Privacy-Protected Contact Tracing System Designed for COVID-19, NIH/NIAAA U01, Co-Investigator, 12/2020-11/2023, $237,567 (Huang lab budget)

A rapid and sensitive technology for direct sensing of intact SARS-CoV-2 virions using designer DNA nanostructure probes and a smartphone fluorimeter, NIH/NIBIB R21, Co-Investigator, 09/2021-09/2023, $105,376 (Huang lab budget)

Regulation of IL10 production in CD8+ T cells during flu infection by tyrosine kinase ITK, NIH/NIAID R01, Co-Investigator, 06/2018-05/2023, $213,120 (Huang lab budget)

Modulation of TCR signaling for sustainable CAR-T therapy, NIH/NIGMS: LSU Center for Pre-Clinical Cancer Research – Pilot, Principal Investigator, 06/2022-02/2023, $74,000

Heterogeneity and molecular signatures of therapeutic T cells in allergic airway inflammation, NIH/NIAID R56, Principal Investigator, 12/2019-11/2022, $375,096

ITK signaling in tissue resident memory T cell development and function in flu-associated pulmonary sequelae, AAI Careers in Immunology Fellowship, Principal Investigator, 09/2021-08/2022, $25,836

Project 2: TCR signaling in IL-10 production by CD8+ T cells during influenza-induced lung immunopathology, NIH/NIGMS P20: LSU-Center for Lung Biology and Disease, Principal Investigator, 01/2019-08/2021, $770,778

GCN2 signaling in pathogenic and regulatory T cell development in allergic airway inflammation, NIH/NIAID R21, Principal Investigator, 06/2018-05/2021, $407,000

A novel murine model of allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 06/2018-05/2020, $443,292

Itk signaling and Type 1 regulatory T cell differentiation and function in allergic airway inflammation, NIH/NIAID R21, Co-Principal Investigator, 12/2017-11/2019, $431,021

ITK signaling in type 2 innate lymphoid cell-mediated pulmonary inflammation and fibrosis, LSU-SVM, Competitive Research Program (CORP), Principal Investigator, 06/2018-01/2019, $9,200

T cell signals in immune balance and host survival during T. gondii infection, NIH/NIGMS: LSU-Tulane Center for Experimental Infectious Disease and Research – Pilot, Principal Investigator, 05/2018-01/2019, $50,00